Pētnieku grupa no Mie universitātes Japānā ir atklājusi, ka agrīnus zebrafish embrijus (embrijus vairākas stundas pēc apaugļošanas) var droši apstarot ar 278 nm UVC.
Sterilizācijai tiek izmantotas UVC-LED aptuveni 260 nm, jo tās izraisa un inaktivē baktēriju un vīrusu DNS bojājumus. Lielākā daļa pašreizējo pētījumu ir vērsta uz UVC ar viļņu garumu zem 240 nm (207 nm, 222 nm, 233 nm) ietekmi uz jaunā koronavīrusa iznīcināšanu. Tomēr ir maz pētījumu par organismu toksicitāti, drošību un reakciju uz UVC apstarošanu ap 280 nm.
Therefore, this time, a total of 16 irradiation doses were set in the range of 0.5 to 60 mJ/cm² using the irradiation device developed by the research group to irradiate 278 nm UVC, and zebrafish embryos were directly irradiated.
After 3 days of irradiation, the researchers evaluated the survival rate, hatching rate, heart rate, deformity rate, etc. of zebrafish embryos. The results found that all embryos remained alive under the irradiation dose below 4.5mJ/cm². However, when the dose reached 7.5 mJ/cm², the deformity rate significantly increased to 82 percent , and the survival rate decreased to 37 percent . Embryo death was observed if the dose was increased to 10 mJ/cm² and above.
Based on the above experimental results, the researchers determined that there is a biological defense system inside the zebrafish embryo, which can resist the damage caused by UVC irradiation to the greatest extent, and the limit dose that can resist UVC irradiation is 4.5 mJ/cm².
The researchers believe that the biological defense mechanism of zebrafish against UVC-induced DNA damage is that after zebrafish embryos are treated with UVC at a dose of 4.5 mJ/cm², the p53 signaling pathway in cells is immediately and urgently activated. Arrest, DNA repair, cell division/proliferation and damaged cell death in rapid response to stress. In addition, after 3 days of recovery, p53 variability was attenuated and instead activated the STAT signaling pathway, which continued to repair damaged DNA.
Šīs tēmas izpētes rezultāti sniedz zinātnisku pamatojumu UVC{0}}LED drošībai, ko izmanto cilvēka ķermenī. Vienlaikus pētnieku grupa atklāja, ka UVC ir piemērota baktēriju un vīrusu, tostarp koronavīrusa, dezinfekcijai, kā arī dezinfekcijai akvakultūrā.
"Experts say UV" believes that: at the application level, the sterilization experience of UVC-LED is difficult to intuitively perceive, and consumers will have concerns about safety when using it. brings confidence.
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